| Lyons to Elyria (Ohio) | 296.69 mi (477.47 km) |
| Lyons to Emeryville (California) | 1,837.28 mi (2,956.81 km) |
| Lyons to Emmaus (Pennsylvania) | 646.27 mi (1,040.07 km) |
| Lyons to Emporia (Kansas) | 500.99 mi (806.26 km) |
| Lyons to Encinitas (California) | 1,714.76 mi (2,759.65 km) |
| Lyons to Endicott (New York) | 603.86 mi (971.82 km) |
| Lyons to Endwell (New York) | 605.96 mi (975.20 km) |
| Lyons to Englewood (Colorado) | 910.04 mi (1,464.56 km) |
| Lyons to Englewood (Florida) | 1,071.06 mi (1,723.71 km) |
| Lyons to Englewood (New Jersey) | 720.13 mi (1,158.94 km) |
| Lyons to Englewood (Ohio) | 227.59 mi (366.27 km) |
| Lyons to Enid (Oklahoma) | 654.92 mi (1,053.99 km) |
| Lyons to Ennis (Texas) | 814.98 mi (1,311.58 km) |
| Lyons to Ensley (Florida) | 780.38 mi (1,255.89 km) |
| Lyons to Enterprise (Alabama) | 732.57 mi (1,178.95 km) |
