| Lubbock to Southern Pines (North Carolina) | 1,284.30 mi (2,066.89 km) |
| Lubbock to Southfield (Michigan) | 1,182.25 mi (1,902.65 km) |
| Lubbock to Southgate (Michigan) | 1,176.92 mi (1,894.07 km) |
| Lubbock to Southlake (Texas) | 276.93 mi (445.67 km) |
| Lubbock to Spanaway (Washington) | 1,421.81 mi (2,288.18 km) |
| Lubbock to Spanish Fork (Utah) | 702.99 mi (1,131.36 km) |
| Lubbock to Spanish Lake (Missouri) | 743.84 mi (1,197.09 km) |
| Lubbock to Spanish Springs (Nevada) | 1,069.79 mi (1,721.66 km) |
| Lubbock to Sparks (Nevada) | 1,070.44 mi (1,722.71 km) |
| Lubbock to Spartanburg (South Carolina) | 1,142.12 mi (1,838.06 km) |
| Lubbock to Spearfish (South Dakota) | 761.85 mi (1,226.08 km) |
| Lubbock to Speedway (Indiana) | 965.70 mi (1,554.14 km) |
| Lubbock to Spencer (Iowa) | 755.26 mi (1,215.47 km) |
| Lubbock to Spokane (Washington) | 1,265.49 mi (2,036.61 km) |
| Lubbock to Spokane Valley (Washington) | 1,258.74 mi (2,025.74 km) |
