| Louisville to University Place (Washington) | 1,954.38 mi (3,145.27 km) |
| Louisville to Upland (California) | 1,798.83 mi (2,894.94 km) |
| Louisville to Upper Arlington (Ohio) | 188.78 mi (303.81 km) |
| Louisville to Upper Grand Lagoon (Florida) | 552.58 mi (889.30 km) |
| Louisville to Upper Montclair (New Jersey) | 637.15 mi (1,025.39 km) |
| Louisville to Urbana (Illinois) | 191.57 mi (308.30 km) |
| Louisville to Urbana (Maryland) | 454.56 mi (731.54 km) |
| Louisville to Urbana (Ohio) | 168.26 mi (270.79 km) |
| Louisville to Urbandale (Iowa) | 493.04 mi (793.46 km) |
| Louisville to Utica (New York) | 643.24 mi (1,035.19 km) |
| Louisville to Uvalde (Texas) | 1,018.90 mi (1,639.76 km) |
| Louisville to Vacaville (California) | 1,957.42 mi (3,150.17 km) |
| Louisville to Vadnais Heights (Minnesota) | 610.87 mi (983.09 km) |
| Louisville to Vail (Arizona) | 1,472.92 mi (2,370.44 km) |
| Louisville to Valdosta (Georgia) | 523.13 mi (841.90 km) |
