| Louisville to Superior (Colorado) | 1,051.84 mi (1,692.78 km) |
| Louisville to Superior (Wisconsin) | 673.85 mi (1,084.46 km) |
| Louisville to Surprise (Arizona) | 1,525.71 mi (2,455.39 km) |
| Louisville to Susanville (California) | 1,863.92 mi (2,999.68 km) |
| Louisville to Sussex (Wisconsin) | 368.79 mi (593.52 km) |
| Louisville to Suwanee (Georgia) | 297.70 mi (479.10 km) |
| Louisville to Swansea (Illinois) | 236.46 mi (380.55 km) |
| Louisville to Sweetwater (Florida) | 909.54 mi (1,463.76 km) |
| Louisville to Sweetwater (Texas) | 919.09 mi (1,479.14 km) |
| Louisville to Sycamore (Illinois) | 309.34 mi (497.84 km) |
| Louisville to Sylacauga (Alabama) | 346.36 mi (557.42 km) |
| Louisville to Sylvania (Ohio) | 265.51 mi (427.29 km) |
| Louisville to Syosset (New York) | 672.39 mi (1,082.11 km) |
| Louisville to Syracuse (New York) | 601.09 mi (967.36 km) |
| Louisville to Syracuse (Utah) | 1,414.93 mi (2,277.11 km) |
