| Louisville to Southern Pines (North Carolina) | 402.28 mi (647.41 km) |
| Louisville to Southfield (Michigan) | 323.25 mi (520.22 km) |
| Louisville to Southgate (Michigan) | 307.34 mi (494.62 km) |
| Louisville to Southlake (Texas) | 739.20 mi (1,189.62 km) |
| Louisville to Spanaway (Washington) | 1,947.93 mi (3,134.89 km) |
| Louisville to Spanish Fork (Utah) | 1,394.39 mi (2,244.06 km) |
| Louisville to Spanish Lake (Missouri) | 250.30 mi (402.81 km) |
| Louisville to Spanish Springs (Nevada) | 1,821.00 mi (2,930.62 km) |
| Louisville to Sparks (Nevada) | 1,824.25 mi (2,935.85 km) |
| Louisville to Spartanburg (South Carolina) | 303.70 mi (488.76 km) |
| Louisville to Spearfish (South Dakota) | 1,035.94 mi (1,667.18 km) |
| Louisville to Speedway (Indiana) | 116.96 mi (188.23 km) |
| Louisville to Spencer (Iowa) | 604.89 mi (973.47 km) |
| Louisville to Spokane (Washington) | 1,721.95 mi (2,771.21 km) |
| Louisville to Spokane Valley (Washington) | 1,712.82 mi (2,756.52 km) |
