| Louisville to Seymour (Tennessee) | 189.10 mi (304.33 km) |
| Louisville to Shady Hills (Florida) | 697.75 mi (1,122.92 km) |
| Louisville to Shafter (California) | 1,854.89 mi (2,985.16 km) |
| Louisville to Shaker Heights (Ohio) | 315.45 mi (507.67 km) |
| Louisville to Shakopee (Minnesota) | 609.93 mi (981.59 km) |
| Louisville to Sharon (Pennsylvania) | 346.07 mi (556.95 km) |
| Louisville to Sharonville (Ohio) | 102.10 mi (164.32 km) |
| Louisville to Shasta Lake (California) | 1,953.76 mi (3,144.27 km) |
| Louisville to Shawnee (Kansas) | 497.89 mi (801.27 km) |
| Louisville to Shawnee (Oklahoma) | 655.35 mi (1,054.69 km) |
| Louisville to Sheboygan (Wisconsin) | 400.13 mi (643.95 km) |
| Louisville to Shelby (North Carolina) | 301.80 mi (485.70 km) |
| Louisville to Shelbyville (Indiana) | 94.84 mi (152.64 km) |
| Louisville to Shelbyville (Kentucky) | 22.94 mi (36.92 km) |
| Louisville to Shelbyville (Tennessee) | 189.59 mi (305.11 km) |
