| Louisville to Security-Widefield (Colorado) | 1,030.47 mi (1,658.38 km) |
| Louisville to Sedalia (Missouri) | 412.10 mi (663.22 km) |
| Louisville to Sedro-Woolley (Washington) | 1,949.88 mi (3,138.02 km) |
| Louisville to Seguin (Texas) | 920.75 mi (1,481.81 km) |
| Louisville to Selden (New York) | 696.48 mi (1,120.88 km) |
| Louisville to Selma (Alabama) | 404.86 mi (651.55 km) |
| Louisville to Selma (California) | 1,857.95 mi (2,990.07 km) |
| Louisville to Selma (Texas) | 936.07 mi (1,506.45 km) |
| Louisville to Seminole (Florida) | 732.18 mi (1,178.33 km) |
| Louisville to Seven Hills (Ohio) | 306.31 mi (492.96 km) |
| Louisville to Seven Oaks (South Carolina) | 379.66 mi (611.01 km) |
| Louisville to Severn (Maryland) | 487.51 mi (784.57 km) |
| Louisville to Severna Park (Maryland) | 494.00 mi (795.02 km) |
| Louisville to Sevierville (Tennessee) | 194.85 mi (313.57 km) |
| Louisville to Seymour (Indiana) | 55.55 mi (89.40 km) |
