| Louisville to Scottsboro (Alabama) | 244.40 mi (393.32 km) |
| Louisville to Scottsdale (Arizona) | 1,493.79 mi (2,404.02 km) |
| Louisville to Scranton (Pennsylvania) | 574.90 mi (925.22 km) |
| Louisville to Seabrook (Maryland) | 478.39 mi (769.89 km) |
| Louisville to Seabrook (Texas) | 800.08 mi (1,287.61 km) |
| Louisville to Seaford (New York) | 670.87 mi (1,079.67 km) |
| Louisville to Seagoville (Texas) | 721.50 mi (1,161.14 km) |
| Louisville to Seal Beach (California) | 1,829.18 mi (2,943.79 km) |
| Louisville to Searcy (Arkansas) | 392.94 mi (632.38 km) |
| Louisville to Seaside (California) | 1,975.82 mi (3,179.77 km) |
| Louisville to SeaTac (Washington) | 1,944.32 mi (3,129.09 km) |
| Louisville to Seattle (Washington) | 1,946.76 mi (3,133.01 km) |
| Louisville to Sebastian (Florida) | 777.09 mi (1,250.61 km) |
| Louisville to Sebring (Florida) | 777.44 mi (1,251.17 km) |
| Louisville to Secaucus (New Jersey) | 643.06 mi (1,034.90 km) |
