| Louisville to Oswego (Illinois) | 281.65 mi (453.28 km) |
| Louisville to Oswego (New York) | 601.24 mi (967.61 km) |
| Louisville to Otsego (Minnesota) | 639.38 mi (1,028.98 km) |
| Louisville to Ottawa (Illinois) | 277.51 mi (446.62 km) |
| Louisville to Ottawa (Kansas) | 521.38 mi (839.08 km) |
| Louisville to Ottumwa (Iowa) | 410.67 mi (660.91 km) |
| Louisville to Overland (Missouri) | 258.07 mi (415.33 km) |
| Louisville to Overland Park (Kansas) | 490.88 mi (790.00 km) |
| Louisville to Overlea (Maryland) | 498.60 mi (802.43 km) |
| Louisville to Oviedo (Florida) | 705.29 mi (1,135.06 km) |
| Louisville to Owasso (Oklahoma) | 574.71 mi (924.90 km) |
| Louisville to Owatonna (Minnesota) | 568.12 mi (914.30 km) |
| Louisville to Owensboro (Kentucky) | 84.84 mi (136.54 km) |
| Louisville to Owings Mills (Maryland) | 484.49 mi (779.72 km) |
| Louisville to Owosso (Michigan) | 342.48 mi (551.17 km) |
