| Louisville to Enterprise (Nevada) | 1,630.19 mi (2,623.53 km) |
| Louisville to Enumclaw (Washington) | 1,928.29 mi (3,103.29 km) |
| Louisville to Ephrata (Pennsylvania) | 525.56 mi (845.81 km) |
| Louisville to Erie (Colorado) | 1,045.63 mi (1,682.78 km) |
| Louisville to Erie (Pennsylvania) | 401.35 mi (645.90 km) |
| Louisville to Erlanger (Kentucky) | 81.83 mi (131.69 km) |
| Louisville to Escanaba (Michigan) | 529.01 mi (851.36 km) |
| Louisville to Escondido (California) | 1,789.26 mi (2,879.53 km) |
| Louisville to Española (New Mexico) | 1,133.05 mi (1,823.46 km) |
| Louisville to Essex (Maryland) | 501.98 mi (807.86 km) |
| Louisville to Essex Junction (Vermont) | 782.11 mi (1,258.69 km) |
| Louisville to Estelle (Louisiana) | 628.79 mi (1,011.94 km) |
| Louisville to Estero (Florida) | 841.48 mi (1,354.22 km) |
| Louisville to Euclid (Ohio) | 322.28 mi (518.65 km) |
| Louisville to Eufaula (Alabama) | 433.17 mi (697.12 km) |
