| Louisville to Elyria (Ohio) | 290.76 mi (467.93 km) |
| Louisville to Emeryville (California) | 1,982.03 mi (3,189.77 km) |
| Louisville to Emmaus (Pennsylvania) | 566.11 mi (911.07 km) |
| Louisville to Emporia (Kansas) | 571.81 mi (920.23 km) |
| Louisville to Encinitas (California) | 1,801.55 mi (2,899.32 km) |
| Louisville to Endicott (New York) | 574.10 mi (923.92 km) |
| Louisville to Endwell (New York) | 576.64 mi (928.02 km) |
| Louisville to Englewood (Colorado) | 1,043.13 mi (1,678.76 km) |
| Louisville to Englewood (Florida) | 796.76 mi (1,282.26 km) |
| Louisville to Englewood (New Jersey) | 649.46 mi (1,045.20 km) |
| Louisville to Englewood (Ohio) | 137.66 mi (221.54 km) |
| Louisville to Enid (Oklahoma) | 682.22 mi (1,097.93 km) |
| Louisville to Ennis (Texas) | 738.88 mi (1,189.11 km) |
| Louisville to Ensley (Florida) | 535.95 mi (862.52 km) |
| Louisville to Enterprise (Alabama) | 472.65 mi (760.65 km) |
