| Los Alamos to Southern Pines (North Carolina) | 1,507.33 mi (2,425.81 km) |
| Los Alamos to Southfield (Michigan) | 1,309.33 mi (2,107.16 km) |
| Los Alamos to Southgate (Michigan) | 1,308.08 mi (2,105.16 km) |
| Los Alamos to Southlake (Texas) | 558.57 mi (898.94 km) |
| Los Alamos to Spanaway (Washington) | 1,134.61 mi (1,825.97 km) |
| Los Alamos to Spanish Fork (Utah) | 412.02 mi (663.08 km) |
| Los Alamos to Spanish Lake (Missouri) | 904.31 mi (1,455.34 km) |
| Los Alamos to Spanish Springs (Nevada) | 774.85 mi (1,247.01 km) |
| Los Alamos to Sparks (Nevada) | 775.75 mi (1,248.45 km) |
| Los Alamos to Spartanburg (South Carolina) | 1,369.72 mi (2,204.35 km) |
| Los Alamos to Spearfish (South Dakota) | 608.14 mi (978.70 km) |
| Los Alamos to Speedway (Indiana) | 1,123.43 mi (1,807.99 km) |
| Los Alamos to Spencer (Iowa) | 775.51 mi (1,248.06 km) |
| Los Alamos to Spokane (Washington) | 993.61 mi (1,599.07 km) |
| Los Alamos to Spokane Valley (Washington) | 987.58 mi (1,589.36 km) |
