| Little Rock to Southern Pines (North Carolina) | 733.71 mi (1,180.80 km) |
| Little Rock to Southfield (Michigan) | 725.83 mi (1,168.11 km) |
| Little Rock to Southgate (Michigan) | 714.82 mi (1,150.39 km) |
| Little Rock to Southlake (Texas) | 300.99 mi (484.39 km) |
| Little Rock to Spanaway (Washington) | 1,771.86 mi (2,851.54 km) |
| Little Rock to Spanish Fork (Utah) | 1,118.89 mi (1,800.67 km) |
| Little Rock to Spanish Lake (Missouri) | 304.87 mi (490.65 km) |
| Little Rock to Spanish Springs (Nevada) | 1,535.02 mi (2,470.37 km) |
| Little Rock to Sparks (Nevada) | 1,537.09 mi (2,473.71 km) |
| Little Rock to Spartanburg (South Carolina) | 591.58 mi (952.05 km) |
| Little Rock to Spearfish (South Dakota) | 907.73 mi (1,460.85 km) |
| Little Rock to Speedway (Indiana) | 485.03 mi (780.59 km) |
| Little Rock to Spencer (Iowa) | 600.83 mi (966.95 km) |
| Little Rock to Spokane (Washington) | 1,569.49 mi (2,525.85 km) |
| Little Rock to Spokane Valley (Washington) | 1,561.04 mi (2,512.25 km) |
