| Little Rock to Scottsboro (Alabama) | 358.41 mi (576.80 km) |
| Little Rock to Scottsdale (Arizona) | 1,115.24 mi (1,794.80 km) |
| Little Rock to Scranton (Pennsylvania) | 1,016.18 mi (1,635.39 km) |
| Little Rock to Seabrook (Maryland) | 904.96 mi (1,456.40 km) |
| Little Rock to Seabrook (Texas) | 388.49 mi (625.21 km) |
| Little Rock to Seaford (New York) | 1,107.27 mi (1,781.98 km) |
| Little Rock to Seagoville (Texas) | 280.09 mi (450.76 km) |
| Little Rock to Seal Beach (California) | 1,466.27 mi (2,359.74 km) |
| Little Rock to Searcy (Arkansas) | 50.14 mi (80.70 km) |
| Little Rock to Seaside (California) | 1,652.36 mi (2,659.22 km) |
| Little Rock to SeaTac (Washington) | 1,773.85 mi (2,854.74 km) |
| Little Rock to Seattle (Washington) | 1,778.95 mi (2,862.94 km) |
| Little Rock to Sebastian (Florida) | 848.79 mi (1,366.00 km) |
| Little Rock to Sebring (Florida) | 815.80 mi (1,312.91 km) |
| Little Rock to Secaucus (New Jersey) | 1,080.63 mi (1,739.11 km) |
