| Little Rock to Sanford (Maine) | 1,299.84 mi (2,091.88 km) |
| Little Rock to Sanford (North Carolina) | 746.33 mi (1,201.10 km) |
| Little Rock to Sanger (California) | 1,526.89 mi (2,457.29 km) |
| Little Rock to Santa Ana (California) | 1,455.76 mi (2,342.81 km) |
| Little Rock to Santa Barbara (California) | 1,551.92 mi (2,497.57 km) |
| Little Rock to Santa Clara (California) | 1,657.40 mi (2,667.33 km) |
| Little Rock to Santa Clara (Oregon) | 1,753.44 mi (2,821.89 km) |
| Little Rock to Santa Clarita (California) | 1,483.04 mi (2,386.72 km) |
| Little Rock to Santa Cruz (California) | 1,662.52 mi (2,675.57 km) |
| Little Rock to Santa Fe (New Mexico) | 771.36 mi (1,241.39 km) |
| Little Rock to Santa Fe (Texas) | 402.14 mi (647.17 km) |
| Little Rock to Santa Fe Springs (California) | 1,463.70 mi (2,355.59 km) |
| Little Rock to Santa Maria (California) | 1,587.66 mi (2,555.10 km) |
| Little Rock to Santa Monica (California) | 1,486.34 mi (2,392.03 km) |
| Little Rock to Santa Paula (California) | 1,515.78 mi (2,439.42 km) |
