| Little Rock to Enterprise (Nevada) | 1,288.65 mi (2,073.89 km) |
| Little Rock to Enumclaw (Washington) | 1,754.77 mi (2,824.03 km) |
| Little Rock to Ephrata (Pennsylvania) | 962.16 mi (1,548.45 km) |
| Little Rock to Erie (Colorado) | 786.10 mi (1,265.10 km) |
| Little Rock to Erie (Pennsylvania) | 836.99 mi (1,347.01 km) |
| Little Rock to Erlanger (Kentucky) | 521.40 mi (839.11 km) |
| Little Rock to Escanaba (Michigan) | 810.18 mi (1,303.85 km) |
| Little Rock to Escondido (California) | 1,417.53 mi (2,281.30 km) |
| Little Rock to Española (New Mexico) | 776.91 mi (1,250.32 km) |
| Little Rock to Essex (Maryland) | 931.56 mi (1,499.20 km) |
| Little Rock to Essex Junction (Vermont) | 1,221.76 mi (1,966.23 km) |
| Little Rock to Estelle (Louisiana) | 362.03 mi (582.63 km) |
| Little Rock to Estero (Florida) | 849.59 mi (1,367.28 km) |
| Little Rock to Euclid (Ohio) | 755.08 mi (1,215.18 km) |
| Little Rock to Eufaula (Alabama) | 459.18 mi (738.98 km) |
