| Little Elm to Southern Pines (North Carolina) | 1,009.84 mi (1,625.19 km) |
| Little Elm to Southfield (Michigan) | 981.87 mi (1,580.16 km) |
| Little Elm to Southgate (Michigan) | 973.14 mi (1,566.12 km) |
| Little Elm to Southlake (Texas) | 20.47 mi (32.94 km) |
| Little Elm to Spanaway (Washington) | 1,642.13 mi (2,642.75 km) |
| Little Elm to Spanish Fork (Utah) | 943.65 mi (1,518.65 km) |
| Little Elm to Spanish Lake (Missouri) | 539.19 mi (867.74 km) |
| Little Elm to Spanish Springs (Nevada) | 1,336.55 mi (2,150.97 km) |
| Little Elm to Sparks (Nevada) | 1,337.76 mi (2,152.91 km) |
| Little Elm to Spartanburg (South Carolina) | 866.51 mi (1,394.52 km) |
| Little Elm to Spearfish (South Dakota) | 863.76 mi (1,390.09 km) |
| Little Elm to Speedway (Indiana) | 747.73 mi (1,203.36 km) |
| Little Elm to Spencer (Iowa) | 694.92 mi (1,118.37 km) |
| Little Elm to Spokane (Washington) | 1,462.57 mi (2,353.77 km) |
| Little Elm to Spokane Valley (Washington) | 1,454.91 mi (2,341.44 km) |
