| Lexington to Enterprise (Nevada) | 1,695.34 mi (2,728.39 km) |
| Lexington to Enumclaw (Washington) | 1,988.30 mi (3,199.85 km) |
| Lexington to Ephrata (Pennsylvania) | 467.50 mi (752.37 km) |
| Lexington to Erie (Colorado) | 1,110.55 mi (1,787.25 km) |
| Lexington to Erie (Pennsylvania) | 364.58 mi (586.74 km) |
| Lexington to Erlanger (Kentucky) | 67.28 mi (108.27 km) |
| Lexington to Escanaba (Michigan) | 549.24 mi (883.91 km) |
| Lexington to Escondido (California) | 1,853.78 mi (2,983.37 km) |
| Lexington to Española (New Mexico) | 1,197.63 mi (1,927.40 km) |
| Lexington to Essex (Maryland) | 440.81 mi (709.41 km) |
| Lexington to Essex Junction (Vermont) | 737.49 mi (1,186.88 km) |
| Lexington to Estelle (Louisiana) | 651.92 mi (1,049.16 km) |
| Lexington to Estero (Florida) | 817.34 mi (1,315.39 km) |
| Lexington to Euclid (Ohio) | 290.54 mi (467.57 km) |
| Lexington to Eufaula (Alabama) | 425.49 mi (684.76 km) |
