| Lexington to Elyria (Ohio) | 262.07 mi (421.76 km) |
| Lexington to Emeryville (California) | 2,047.15 mi (3,294.57 km) |
| Lexington to Emmaus (Pennsylvania) | 508.92 mi (819.02 km) |
| Lexington to Emporia (Kansas) | 637.01 mi (1,025.17 km) |
| Lexington to Encinitas (California) | 1,866.07 mi (3,003.14 km) |
| Lexington to Endicott (New York) | 524.54 mi (844.16 km) |
| Lexington to Endwell (New York) | 527.11 mi (848.29 km) |
| Lexington to Englewood (Colorado) | 1,108.19 mi (1,783.46 km) |
| Lexington to Englewood (Florida) | 774.62 mi (1,246.63 km) |
| Lexington to Englewood (New Jersey) | 592.45 mi (953.45 km) |
| Lexington to Englewood (Ohio) | 126.15 mi (203.02 km) |
| Lexington to Enid (Oklahoma) | 745.78 mi (1,200.22 km) |
| Lexington to Ennis (Texas) | 791.98 mi (1,274.56 km) |
| Lexington to Ensley (Florida) | 543.54 mi (874.74 km) |
| Lexington to Enterprise (Alabama) | 470.58 mi (757.32 km) |
