| Lewes to Southern Pines (North Carolina) | 3,951.62 mi (6,359.51 km) |
| Lewes to Southfield (Michigan) | 3,776.82 mi (6,078.20 km) |
| Lewes to Southgate (Michigan) | 3,786.71 mi (6,094.12 km) |
| Lewes to Southlake (Texas) | 4,777.55 mi (7,688.72 km) |
| Lewes to Spanaway (Washington) | 4,854.00 mi (7,811.76 km) |
| Lewes to Spanish Fork (Utah) | 4,921.70 mi (7,920.71 km) |
| Lewes to Spanish Lake (Missouri) | 4,217.93 mi (6,788.11 km) |
| Lewes to Spanish Springs (Nevada) | 5,199.58 mi (8,367.92 km) |
| Lewes to Sparks (Nevada) | 5,205.73 mi (8,377.81 km) |
| Lewes to Spartanburg (South Carolina) | 4,067.92 mi (6,546.69 km) |
| Lewes to Spearfish (South Dakota) | 4,432.09 mi (7,132.76 km) |
| Lewes to Speedway (Indiana) | 4,015.72 mi (6,462.67 km) |
| Lewes to Spencer (Iowa) | 4,195.35 mi (6,751.76 km) |
| Lewes to Spokane (Washington) | 4,685.45 mi (7,540.50 km) |
| Lewes to Spokane Valley (Washington) | 4,680.10 mi (7,531.90 km) |
