| League City to Southern Pines (North Carolina) | 996.41 mi (1,603.57 km) |
| League City to Southfield (Michigan) | 1,113.04 mi (1,791.26 km) |
| League City to Southgate (Michigan) | 1,100.57 mi (1,771.19 km) |
| League City to Southlake (Texas) | 268.19 mi (431.62 km) |
| League City to Spanaway (Washington) | 1,899.61 mi (3,057.12 km) |
| League City to Spanish Fork (Utah) | 1,187.55 mi (1,911.18 km) |
| League City to Spanish Lake (Missouri) | 700.79 mi (1,127.82 km) |
| League City to Spanish Springs (Nevada) | 1,556.92 mi (2,505.61 km) |
| League City to Sparks (Nevada) | 1,557.38 mi (2,506.36 km) |
| League City to Spartanburg (South Carolina) | 856.94 mi (1,379.10 km) |
| League City to Spearfish (South Dakota) | 1,140.95 mi (1,836.19 km) |
| League City to Speedway (Indiana) | 871.18 mi (1,402.02 km) |
| League City to Spencer (Iowa) | 943.78 mi (1,518.86 km) |
| League City to Spokane (Washington) | 1,728.85 mi (2,782.31 km) |
| League City to Spokane Valley (Washington) | 1,721.45 mi (2,770.41 km) |
