| League City to Seymour (Tennessee) | 792.84 mi (1,275.95 km) |
| League City to Shady Hills (Florida) | 762.82 mi (1,227.64 km) |
| League City to Shafter (California) | 1,459.70 mi (2,349.15 km) |
| League City to Shaker Heights (Ohio) | 1,123.23 mi (1,807.66 km) |
| League City to Shakopee (Minnesota) | 1,059.99 mi (1,705.89 km) |
| League City to Sharon (Pennsylvania) | 1,152.87 mi (1,855.37 km) |
| League City to Sharonville (Ohio) | 909.86 mi (1,464.28 km) |
| League City to Shasta Lake (California) | 1,714.99 mi (2,760.02 km) |
| League City to Shawnee (Kansas) | 658.57 mi (1,059.87 km) |
| League City to Shawnee (Oklahoma) | 419.46 mi (675.06 km) |
| League City to Sheboygan (Wisconsin) | 1,065.27 mi (1,714.38 km) |
| League City to Shelby (North Carolina) | 886.00 mi (1,425.87 km) |
| League City to Shelbyville (Indiana) | 873.01 mi (1,404.97 km) |
| League City to Shelbyville (Kentucky) | 826.22 mi (1,329.67 km) |
| League City to Shelbyville (Tennessee) | 652.97 mi (1,050.86 km) |
