| League City to Security-Widefield (Colorado) | 842.37 mi (1,355.66 km) |
| League City to Sedalia (Missouri) | 645.86 mi (1,039.41 km) |
| League City to Sedro-Woolley (Washington) | 1,942.87 mi (3,126.75 km) |
| League City to Seguin (Texas) | 172.00 mi (276.80 km) |
| League City to Selden (New York) | 1,466.91 mi (2,360.76 km) |
| League City to Selma (Alabama) | 519.33 mi (835.78 km) |
| League City to Selma (California) | 1,496.53 mi (2,408.43 km) |
| League City to Selma (Texas) | 192.75 mi (310.20 km) |
| League City to Seminole (Florida) | 755.39 mi (1,215.68 km) |
| League City to Seven Hills (Ohio) | 1,114.10 mi (1,792.96 km) |
| League City to Seven Oaks (South Carolina) | 877.81 mi (1,412.70 km) |
| League City to Severn (Maryland) | 1,240.70 mi (1,996.71 km) |
| League City to Severna Park (Maryland) | 1,245.27 mi (2,004.06 km) |
| League City to Sevierville (Tennessee) | 802.76 mi (1,291.92 km) |
| League City to Seymour (Indiana) | 838.39 mi (1,349.25 km) |
