| League City to Scottsboro (Alabama) | 638.55 mi (1,027.64 km) |
| League City to Scottsdale (Arizona) | 1,026.65 mi (1,652.23 km) |
| League City to Scranton (Pennsylvania) | 1,364.17 mi (2,195.42 km) |
| League City to Seabrook (Maryland) | 1,228.45 mi (1,977.01 km) |
| League City to Seabrook (Texas) | 7.93 mi (12.77 km) |
| League City to Seaford (New York) | 1,439.80 mi (2,317.14 km) |
| League City to Seagoville (Texas) | 234.66 mi (377.65 km) |
| League City to Seal Beach (California) | 1,379.70 mi (2,220.42 km) |
| League City to Searcy (Arkansas) | 443.58 mi (713.88 km) |
| League City to Seaside (California) | 1,617.31 mi (2,602.81 km) |
| League City to SeaTac (Washington) | 1,906.71 mi (3,068.55 km) |
| League City to Seattle (Washington) | 1,914.02 mi (3,080.32 km) |
| League City to Sebastian (Florida) | 894.19 mi (1,439.05 km) |
| League City to Sebring (Florida) | 840.35 mi (1,352.41 km) |
| League City to Secaucus (New Jersey) | 1,416.31 mi (2,279.33 km) |
