| League City to Santa Rosa (California) | 1,690.19 mi (2,720.10 km) |
| League City to Santaquin (Utah) | 1,189.19 mi (1,913.81 km) |
| League City to Santee (California) | 1,311.58 mi (2,110.78 km) |
| League City to Sapulpa (Oklahoma) | 454.27 mi (731.07 km) |
| League City to Saraland (Alabama) | 428.98 mi (690.38 km) |
| League City to Sarasota (Florida) | 777.48 mi (1,251.24 km) |
| League City to Sarasota Springs (Florida) | 782.07 mi (1,258.62 km) |
| League City to Saratoga (California) | 1,636.73 mi (2,634.06 km) |
| League City to Saratoga Springs (New York) | 1,506.31 mi (2,424.18 km) |
| League City to Saratoga Springs (Utah) | 1,208.56 mi (1,944.99 km) |
| League City to Sartell (Minnesota) | 1,115.61 mi (1,795.41 km) |
| League City to Satellite Beach (Florida) | 882.13 mi (1,419.65 km) |
| League City to Sauk Rapids (Minnesota) | 1,114.35 mi (1,793.37 km) |
| League City to Sault Ste. Marie (Michigan) | 1,308.84 mi (2,106.38 km) |
| League City to Savage (Minnesota) | 1,059.16 mi (1,704.55 km) |
