| League City to Sanford (Maine) | 1,650.72 mi (2,656.58 km) |
| League City to Sanford (North Carolina) | 1,015.21 mi (1,633.82 km) |
| League City to Sanger (California) | 1,495.31 mi (2,406.46 km) |
| League City to Santa Ana (California) | 1,368.75 mi (2,202.79 km) |
| League City to Santa Barbara (California) | 1,478.59 mi (2,379.56 km) |
| League City to Santa Clara (California) | 1,634.90 mi (2,631.11 km) |
| League City to Santa Clara (Oregon) | 1,836.56 mi (2,955.66 km) |
| League City to Santa Clarita (California) | 1,409.27 mi (2,268.00 km) |
| League City to Santa Cruz (California) | 1,633.39 mi (2,628.69 km) |
| League City to Santa Fe (New Mexico) | 762.62 mi (1,227.31 km) |
| League City to Santa Fe (Texas) | 6.82 mi (10.98 km) |
| League City to Santa Fe Springs (California) | 1,380.55 mi (2,221.78 km) |
| League City to Santa Maria (California) | 1,523.53 mi (2,451.89 km) |
| League City to Santa Monica (California) | 1,405.09 mi (2,261.27 km) |
| League City to Santa Paula (California) | 1,440.93 mi (2,318.95 km) |
