| League City to Olympia Heights (Florida) | 940.16 mi (1,513.04 km) |
| League City to Omaha (Nebraska) | 815.32 mi (1,312.12 km) |
| League City to On Top of the World Designated Place (Florida) | 772.67 mi (1,243.49 km) |
| League City to Onalaska (Wisconsin) | 1,017.89 mi (1,638.13 km) |
| League City to Oneida (New York) | 1,427.00 mi (2,296.53 km) |
| League City to Oneonta (New York) | 1,428.44 mi (2,298.86 km) |
| League City to Ontario (California) | 1,355.49 mi (2,181.46 km) |
| League City to Ontario (Oregon) | 1,564.23 mi (2,517.38 km) |
| League City to Opa-locka (Florida) | 941.13 mi (1,514.60 km) |
| League City to Opelika (Alabama) | 615.93 mi (991.25 km) |
| League City to Opelousas (Louisiana) | 194.79 mi (313.48 km) |
| League City to Orange (California) | 1,365.82 mi (2,198.08 km) |
| League City to Orange (Texas) | 91.96 mi (148.00 km) |
| League City to Orange City (Florida) | 833.86 mi (1,341.96 km) |
| League City to Orangeburg (South Carolina) | 882.64 mi (1,420.47 km) |
