| League City to Enterprise (Nevada) | 1,250.00 mi (2,011.68 km) |
| League City to Enumclaw (Washington) | 1,885.69 mi (3,034.72 km) |
| League City to Ephrata (Pennsylvania) | 1,298.65 mi (2,089.97 km) |
| League City to Erie (Colorado) | 920.30 mi (1,481.08 km) |
| League City to Erie (Pennsylvania) | 1,209.35 mi (1,946.27 km) |
| League City to Erlanger (Kentucky) | 889.84 mi (1,432.05 km) |
| League City to Escanaba (Michigan) | 1,204.60 mi (1,938.62 km) |
| League City to Escondido (California) | 1,318.20 mi (2,121.44 km) |
| League City to Española (New Mexico) | 779.14 mi (1,253.91 km) |
| League City to Essex (Maryland) | 1,257.87 mi (2,024.35 km) |
| League City to Essex Junction (Vermont) | 1,586.98 mi (2,553.99 km) |
| League City to Estelle (Louisiana) | 301.57 mi (485.33 km) |
| League City to Estero (Florida) | 839.02 mi (1,350.27 km) |
| League City to Euclid (Ohio) | 1,129.88 mi (1,818.37 km) |
| League City to Eufaula (Alabama) | 614.58 mi (989.07 km) |
