| League City to Elyria (Ohio) | 1,097.71 mi (1,766.59 km) |
| League City to Emeryville (California) | 1,659.05 mi (2,669.98 km) |
| League City to Emmaus (Pennsylvania) | 1,341.95 mi (2,159.67 km) |
| League City to Emporia (Kansas) | 619.11 mi (996.36 km) |
| League City to Encinitas (California) | 1,328.58 mi (2,138.14 km) |
| League City to Endicott (New York) | 1,372.22 mi (2,208.38 km) |
| League City to Endwell (New York) | 1,374.79 mi (2,212.52 km) |
| League City to Englewood (Colorado) | 898.22 mi (1,445.55 km) |
| League City to Englewood (Florida) | 795.29 mi (1,279.90 km) |
| League City to Englewood (New Jersey) | 1,424.07 mi (2,291.82 km) |
| League City to Englewood (Ohio) | 942.28 mi (1,516.45 km) |
| League City to Enid (Oklahoma) | 504.08 mi (811.23 km) |
| League City to Ennis (Texas) | 215.94 mi (347.52 km) |
| League City to Ensley (Florida) | 474.17 mi (763.10 km) |
| League City to Enterprise (Alabama) | 566.20 mi (911.21 km) |
