| Le Mars to Southern Pines (North Carolina) | 1,039.31 mi (1,672.61 km) |
| Le Mars to Southfield (Michigan) | 656.13 mi (1,055.94 km) |
| Le Mars to Southgate (Michigan) | 661.20 mi (1,064.10 km) |
| Le Mars to Southlake (Texas) | 681.02 mi (1,095.99 km) |
| Le Mars to Spanaway (Washington) | 1,311.34 mi (2,110.39 km) |
| Le Mars to Spanish Fork (Utah) | 820.77 mi (1,320.90 km) |
| Le Mars to Spanish Lake (Missouri) | 416.34 mi (670.03 km) |
| Le Mars to Spanish Springs (Nevada) | 1,235.88 mi (1,988.96 km) |
| Le Mars to Sparks (Nevada) | 1,240.01 mi (1,995.60 km) |
| Le Mars to Spartanburg (South Carolina) | 936.42 mi (1,507.03 km) |
| Le Mars to Spearfish (South Dakota) | 399.82 mi (643.44 km) |
| Le Mars to Speedway (Indiana) | 554.65 mi (892.62 km) |
| Le Mars to Spencer (Iowa) | 57.43 mi (92.42 km) |
| Le Mars to Spokane (Washington) | 1,084.22 mi (1,744.88 km) |
| Le Mars to Spokane Valley (Washington) | 1,075.08 mi (1,730.18 km) |
