| Laguna Woods to Southern Pines (North Carolina) | 2,174.12 mi (3,498.91 km) |
| Laguna Woods to Southfield (Michigan) | 1,957.62 mi (3,150.48 km) |
| Laguna Woods to Southgate (Michigan) | 1,958.30 mi (3,151.57 km) |
| Laguna Woods to Southlake (Texas) | 1,187.60 mi (1,911.25 km) |
| Laguna Woods to Spanaway (Washington) | 963.67 mi (1,550.87 km) |
| Laguna Woods to Spanish Fork (Utah) | 560.95 mi (902.76 km) |
| Laguna Woods to Spanish Lake (Missouri) | 1,569.28 mi (2,525.51 km) |
| Laguna Woods to Spanish Springs (Nevada) | 431.38 mi (694.25 km) |
| Laguna Woods to Sparks (Nevada) | 426.49 mi (686.38 km) |
| Laguna Woods to Spartanburg (South Carolina) | 2,035.38 mi (3,275.62 km) |
| Laguna Woods to Spearfish (South Dakota) | 1,056.67 mi (1,700.54 km) |
| Laguna Woods to Speedway (Indiana) | 1,785.58 mi (2,873.62 km) |
| Laguna Woods to Spencer (Iowa) | 1,382.77 mi (2,225.35 km) |
| Laguna Woods to Spokane (Washington) | 971.38 mi (1,563.29 km) |
| Laguna Woods to Spokane Valley (Washington) | 971.29 mi (1,563.14 km) |
