| Laguna Woods to Silver Firs (Washington) | 1,011.20 mi (1,627.37 km) |
| Laguna Woods to Silver Spring (Maryland) | 2,277.90 mi (3,665.93 km) |
| Laguna Woods to Silver Springs Shores (Florida) | 2,119.40 mi (3,410.84 km) |
| Laguna Woods to Silverdale (Washington) | 1,004.77 mi (1,617.02 km) |
| Laguna Woods to Silverton (Oregon) | 831.77 mi (1,338.60 km) |
| Laguna Woods to Simi Valley (California) | 73.96 mi (119.02 km) |
| Laguna Woods to Simpsonville (South Carolina) | 2,018.80 mi (3,248.94 km) |
| Laguna Woods to Sioux City (Iowa) | 1,308.17 mi (2,105.29 km) |
| Laguna Woods to Sioux Falls (South Dakota) | 1,319.96 mi (2,124.27 km) |
| Laguna Woods to Skokie (Illinois) | 1,726.57 mi (2,778.65 km) |
| Laguna Woods to Sleepy Hollow (New York) | 2,437.14 mi (3,922.20 km) |
| Laguna Woods to Slidell (Louisiana) | 1,649.37 mi (2,654.40 km) |
| Laguna Woods to Smithfield (North Carolina) | 2,229.72 mi (3,588.39 km) |
| Laguna Woods to Smithfield (Utah) | 653.08 mi (1,051.03 km) |
| Laguna Woods to Smithville (Missouri) | 1,342.30 mi (2,160.23 km) |
