| Laguna Woods to Scottsboro (Alabama) | 1,805.94 mi (2,906.37 km) |
| Laguna Woods to Scottsdale (Arizona) | 337.32 mi (542.87 km) |
| Laguna Woods to Scranton (Pennsylvania) | 2,343.51 mi (3,771.51 km) |
| Laguna Woods to Seabrook (Maryland) | 2,287.14 mi (3,680.79 km) |
| Laguna Woods to Seabrook (Texas) | 1,362.16 mi (2,192.19 km) |
| Laguna Woods to Seaford (New York) | 2,458.33 mi (3,956.30 km) |
| Laguna Woods to Seagoville (Texas) | 1,225.37 mi (1,972.05 km) |
| Laguna Woods to Seal Beach (California) | 22.02 mi (35.44 km) |
| Laguna Woods to Searcy (Arkansas) | 1,481.56 mi (2,384.34 km) |
| Laguna Woods to Seaside (California) | 311.00 mi (500.50 km) |
| Laguna Woods to SeaTac (Washington) | 985.06 mi (1,585.31 km) |
| Laguna Woods to Seattle (Washington) | 997.15 mi (1,604.75 km) |
| Laguna Woods to Sebastian (Florida) | 2,237.08 mi (3,600.23 km) |
| Laguna Woods to Sebring (Florida) | 2,188.40 mi (3,521.89 km) |
| Laguna Woods to Secaucus (New Jersey) | 2,427.94 mi (3,907.40 km) |
