| La Grande to Superior (Colorado) | 754.07 mi (1,213.56 km) |
| La Grande to Superior (Wisconsin) | 1,245.78 mi (2,004.89 km) |
| La Grande to Surprise (Arizona) | 858.13 mi (1,381.02 km) |
| La Grande to Susanville (California) | 362.11 mi (582.76 km) |
| La Grande to Sussex (Wisconsin) | 1,477.71 mi (2,378.14 km) |
| La Grande to Suwanee (Georgia) | 1,950.88 mi (3,139.64 km) |
| La Grande to Swansea (Illinois) | 1,509.24 mi (2,428.89 km) |
| La Grande to Sweetwater (Florida) | 2,479.90 mi (3,991.02 km) |
| La Grande to Sweetwater (Texas) | 1,295.54 mi (2,084.97 km) |
| La Grande to Sycamore (Illinois) | 1,479.22 mi (2,380.58 km) |
| La Grande to Sylacauga (Alabama) | 1,881.74 mi (3,028.36 km) |
| La Grande to Sylvania (Ohio) | 1,727.08 mi (2,779.46 km) |
| La Grande to Syosset (New York) | 2,242.73 mi (3,609.32 km) |
| La Grande to Syracuse (New York) | 2,060.63 mi (3,316.26 km) |
| La Grande to Syracuse (Utah) | 421.17 mi (677.80 km) |
