| La Grande to Southern Pines (North Carolina) | 2,132.75 mi (3,432.32 km) |
| La Grande to Southfield (Michigan) | 1,731.30 mi (2,786.25 km) |
| La Grande to Southgate (Michigan) | 1,740.01 mi (2,800.27 km) |
| La Grande to Southlake (Texas) | 1,403.21 mi (2,258.24 km) |
| La Grande to Spanaway (Washington) | 240.81 mi (387.55 km) |
| La Grande to Spanish Fork (Utah) | 486.36 mi (782.72 km) |
| La Grande to Spanish Lake (Missouri) | 1,491.14 mi (2,399.76 km) |
| La Grande to Spanish Springs (Nevada) | 399.77 mi (643.37 km) |
| La Grande to Sparks (Nevada) | 405.90 mi (653.23 km) |
| La Grande to Spartanburg (South Carolina) | 2,020.07 mi (3,250.99 km) |
| La Grande to Spearfish (South Dakota) | 699.80 mi (1,126.22 km) |
| La Grande to Speedway (Indiana) | 1,653.20 mi (2,660.57 km) |
| La Grande to Spencer (Iowa) | 1,141.26 mi (1,836.68 km) |
| La Grande to Spokane (Washington) | 164.83 mi (265.27 km) |
| La Grande to Spokane Valley (Washington) | 166.57 mi (268.07 km) |
