| La Crosse to University Place (Washington) | 1,523.68 mi (2,452.13 km) |
| La Crosse to Upland (California) | 1,561.22 mi (2,512.54 km) |
| La Crosse to Upper Arlington (Ohio) | 494.24 mi (795.40 km) |
| La Crosse to Upper Grand Lagoon (Florida) | 990.25 mi (1,593.65 km) |
| La Crosse to Upper Montclair (New Jersey) | 891.94 mi (1,435.43 km) |
| La Crosse to Urbana (Illinois) | 300.03 mi (482.85 km) |
| La Crosse to Urbana (Maryland) | 780.74 mi (1,256.48 km) |
| La Crosse to Urbana (Ohio) | 461.54 mi (742.77 km) |
| La Crosse to Urbandale (Iowa) | 198.98 mi (320.22 km) |
| La Crosse to Utica (New York) | 802.78 mi (1,291.95 km) |
| La Crosse to Uvalde (Texas) | 1,113.96 mi (1,792.75 km) |
| La Crosse to Vacaville (California) | 1,634.55 mi (2,630.55 km) |
| La Crosse to Vadnais Heights (Minnesota) | 124.76 mi (200.79 km) |
| La Crosse to Vail (Arizona) | 1,332.42 mi (2,144.33 km) |
| La Crosse to Valdosta (Georgia) | 995.91 mi (1,602.76 km) |
