| La Crosse to Superior (Colorado) | 764.28 mi (1,229.98 km) |
| La Crosse to Superior (Wisconsin) | 202.61 mi (326.07 km) |
| La Crosse to Surprise (Arizona) | 1,335.32 mi (2,148.99 km) |
| La Crosse to Susanville (California) | 1,516.04 mi (2,439.83 km) |
| La Crosse to Sussex (Wisconsin) | 157.96 mi (254.21 km) |
| La Crosse to Suwanee (Georgia) | 776.43 mi (1,249.55 km) |
| La Crosse to Swansea (Illinois) | 370.01 mi (595.48 km) |
| La Crosse to Sweetwater (Florida) | 1,387.62 mi (2,233.16 km) |
| La Crosse to Sweetwater (Texas) | 928.40 mi (1,494.12 km) |
| La Crosse to Sycamore (Illinois) | 180.38 mi (290.29 km) |
| La Crosse to Sylacauga (Alabama) | 782.66 mi (1,259.58 km) |
| La Crosse to Sylvania (Ohio) | 408.14 mi (656.84 km) |
| La Crosse to Syosset (New York) | 927.11 mi (1,492.04 km) |
| La Crosse to Syracuse (New York) | 757.67 mi (1,219.35 km) |
| La Crosse to Syracuse (Utah) | 1,076.24 mi (1,732.04 km) |
