| La Crosse to Storm Lake (Iowa) | 215.80 mi (347.29 km) |
| La Crosse to Storrs (Connecticut) | 969.56 mi (1,560.35 km) |
| La Crosse to Stoughton (Wisconsin) | 118.33 mi (190.43 km) |
| La Crosse to Stow (Ohio) | 530.91 mi (854.42 km) |
| La Crosse to Streamwood (Illinois) | 198.26 mi (319.08 km) |
| La Crosse to Streator (Illinois) | 222.94 mi (358.79 km) |
| La Crosse to Streetsboro (Ohio) | 533.44 mi (858.49 km) |
| La Crosse to Strongsville (Ohio) | 508.25 mi (817.94 km) |
| La Crosse to Stuart (Florida) | 1,301.65 mi (2,094.81 km) |
| La Crosse to Stuarts Draft (Virginia) | 751.14 mi (1,208.84 km) |
| La Crosse to Sturgis (Michigan) | 325.86 mi (524.42 km) |
| La Crosse to Suamico (Wisconsin) | 166.10 mi (267.32 km) |
| La Crosse to Sudley (Virginia) | 791.72 mi (1,274.15 km) |
| La Crosse to Suffern (New York) | 888.92 mi (1,430.58 km) |
| La Crosse to Suffolk (Virginia) | 911.27 mi (1,466.55 km) |
