| La Crosse to Southern Pines (North Carolina) | 866.04 mi (1,393.75 km) |
| La Crosse to Southfield (Michigan) | 412.04 mi (663.11 km) |
| La Crosse to Southgate (Michigan) | 420.19 mi (676.23 km) |
| La Crosse to Southlake (Texas) | 816.09 mi (1,313.37 km) |
| La Crosse to Spanaway (Washington) | 1,518.32 mi (2,443.51 km) |
| La Crosse to Spanish Fork (Utah) | 1,076.61 mi (1,732.64 km) |
| La Crosse to Spanish Lake (Missouri) | 351.92 mi (566.36 km) |
| La Crosse to Spanish Springs (Nevada) | 1,486.66 mi (2,392.54 km) |
| La Crosse to Sparks (Nevada) | 1,491.00 mi (2,399.54 km) |
| La Crosse to Spartanburg (South Carolina) | 788.33 mi (1,268.70 km) |
| La Crosse to Spearfish (South Dakota) | 625.09 mi (1,005.99 km) |
| La Crosse to Speedway (Indiana) | 378.39 mi (608.96 km) |
| La Crosse to Spencer (Iowa) | 202.31 mi (325.58 km) |
| La Crosse to Spokane (Washington) | 1,284.62 mi (2,067.40 km) |
| La Crosse to Spokane Valley (Washington) | 1,275.38 mi (2,052.53 km) |
