| La Crosse to Smyrna (Delaware) | 864.35 mi (1,391.04 km) |
| La Crosse to Smyrna (Georgia) | 776.54 mi (1,249.72 km) |
| La Crosse to Smyrna (Tennessee) | 596.95 mi (960.70 km) |
| La Crosse to Snellville (Georgia) | 790.08 mi (1,271.51 km) |
| La Crosse to Snoqualmie (Washington) | 1,489.92 mi (2,397.79 km) |
| La Crosse to Snyder (Texas) | 928.76 mi (1,494.70 km) |
| La Crosse to Socastee (South Carolina) | 959.16 mi (1,543.61 km) |
| La Crosse to Socorro (Texas) | 1,172.67 mi (1,887.23 km) |
| La Crosse to Soddy-Daisy (Tennessee) | 673.62 mi (1,084.08 km) |
| La Crosse to Solana Beach (California) | 1,586.08 mi (2,552.56 km) |
| La Crosse to Soledad (California) | 1,659.95 mi (2,671.43 km) |
| La Crosse to Solon (Ohio) | 525.04 mi (844.98 km) |
| La Crosse to Somers Point (New Jersey) | 911.88 mi (1,467.52 km) |
| La Crosse to Somerset (Kentucky) | 580.86 mi (934.80 km) |
| La Crosse to Somerset (New Jersey) | 884.94 mi (1,424.17 km) |
