| La Crosse to Silver Firs (Washington) | 1,503.79 mi (2,420.11 km) |
| La Crosse to Silver Spring (Maryland) | 806.57 mi (1,298.05 km) |
| La Crosse to Silver Springs Shores (Florida) | 1,136.30 mi (1,828.70 km) |
| La Crosse to Silverdale (Washington) | 1,528.85 mi (2,460.44 km) |
| La Crosse to Silverton (Oregon) | 1,549.58 mi (2,493.80 km) |
| La Crosse to Simi Valley (California) | 1,607.91 mi (2,587.68 km) |
| La Crosse to Simpsonville (South Carolina) | 789.59 mi (1,270.72 km) |
| La Crosse to Sioux City (Iowa) | 275.88 mi (443.98 km) |
| La Crosse to Sioux Falls (South Dakota) | 275.69 mi (443.67 km) |
| La Crosse to Skokie (Illinois) | 215.33 mi (346.53 km) |
| La Crosse to Sleepy Hollow (New York) | 902.73 mi (1,452.81 km) |
| La Crosse to Slidell (Louisiana) | 938.55 mi (1,510.44 km) |
| La Crosse to Smithfield (North Carolina) | 891.88 mi (1,435.34 km) |
| La Crosse to Smithfield (Utah) | 1,050.05 mi (1,689.90 km) |
| La Crosse to Smithville (Missouri) | 351.63 mi (565.89 km) |
