| La Crosse to Seymour (Tennessee) | 676.10 mi (1,088.08 km) |
| La Crosse to Shady Hills (Florida) | 1,168.75 mi (1,880.92 km) |
| La Crosse to Shafter (California) | 1,586.50 mi (2,553.22 km) |
| La Crosse to Shaker Heights (Ohio) | 517.52 mi (832.87 km) |
| La Crosse to Shakopee (Minnesota) | 129.21 mi (207.94 km) |
| La Crosse to Sharon (Pennsylvania) | 574.26 mi (924.18 km) |
| La Crosse to Sharonville (Ohio) | 471.72 mi (759.16 km) |
| La Crosse to Shasta Lake (California) | 1,598.28 mi (2,572.18 km) |
| La Crosse to Shawnee (Kansas) | 380.42 mi (612.23 km) |
| La Crosse to Shawnee (Oklahoma) | 659.81 mi (1,061.87 km) |
| La Crosse to Sheboygan (Wisconsin) | 174.44 mi (280.73 km) |
| La Crosse to Shelby (North Carolina) | 782.23 mi (1,258.88 km) |
| La Crosse to Shelbyville (Indiana) | 408.27 mi (657.05 km) |
| La Crosse to Shelbyville (Kentucky) | 498.11 mi (801.63 km) |
| La Crosse to Shelbyville (Tennessee) | 628.52 mi (1,011.50 km) |
