| La Crosse to Security-Widefield (Colorado) | 781.82 mi (1,258.22 km) |
| La Crosse to Sedalia (Missouri) | 368.64 mi (593.28 km) |
| La Crosse to Sedro-Woolley (Washington) | 1,507.52 mi (2,426.11 km) |
| La Crosse to Seguin (Texas) | 1,051.09 mi (1,691.57 km) |
| La Crosse to Selden (New York) | 948.43 mi (1,526.36 km) |
| La Crosse to Selma (Alabama) | 820.17 mi (1,319.94 km) |
| La Crosse to Selma (California) | 1,570.60 mi (2,527.64 km) |
| La Crosse to Selma (Texas) | 1,058.11 mi (1,702.86 km) |
| La Crosse to Seminole (Florida) | 1,199.56 mi (1,930.50 km) |
| La Crosse to Seven Hills (Ohio) | 513.99 mi (827.19 km) |
| La Crosse to Seven Oaks (South Carolina) | 864.62 mi (1,391.47 km) |
| La Crosse to Severn (Maryland) | 817.53 mi (1,315.68 km) |
| La Crosse to Severna Park (Maryland) | 825.10 mi (1,327.88 km) |
| La Crosse to Sevierville (Tennessee) | 681.79 mi (1,097.23 km) |
| La Crosse to Seymour (Indiana) | 435.72 mi (701.22 km) |
