| La Crosse to Scottsboro (Alabama) | 691.81 mi (1,113.36 km) |
| La Crosse to Scottsdale (Arizona) | 1,308.57 mi (2,105.93 km) |
| La Crosse to Scranton (Pennsylvania) | 807.46 mi (1,299.48 km) |
| La Crosse to Seabrook (Maryland) | 815.34 mi (1,312.16 km) |
| La Crosse to Seabrook (Texas) | 1,006.42 mi (1,619.68 km) |
| La Crosse to Seaford (New York) | 930.94 mi (1,498.20 km) |
| La Crosse to Seagoville (Texas) | 823.58 mi (1,325.42 km) |
| La Crosse to Seal Beach (California) | 1,594.74 mi (2,566.48 km) |
| La Crosse to Searcy (Arkansas) | 593.59 mi (955.30 km) |
| La Crosse to Seaside (California) | 1,677.93 mi (2,700.38 km) |
| La Crosse to SeaTac (Washington) | 1,511.44 mi (2,432.43 km) |
| La Crosse to Seattle (Washington) | 1,512.26 mi (2,433.75 km) |
| La Crosse to Sebastian (Florida) | 1,258.81 mi (2,025.86 km) |
| La Crosse to Sebring (Florida) | 1,253.54 mi (2,017.38 km) |
| La Crosse to Secaucus (New Jersey) | 900.00 mi (1,448.41 km) |
