| La Crosse to Santa Rosa (California) | 1,669.01 mi (2,686.02 km) |
| La Crosse to Santaquin (Utah) | 1,087.61 mi (1,750.34 km) |
| La Crosse to Santee (California) | 1,578.93 mi (2,541.05 km) |
| La Crosse to Sapulpa (Oklahoma) | 598.27 mi (962.82 km) |
| La Crosse to Saraland (Alabama) | 912.68 mi (1,468.82 km) |
| La Crosse to Sarasota (Florida) | 1,237.40 mi (1,991.40 km) |
| La Crosse to Sarasota Springs (Florida) | 1,240.83 mi (1,996.92 km) |
| La Crosse to Saratoga (California) | 1,668.52 mi (2,685.23 km) |
| La Crosse to Saratoga Springs (New York) | 875.25 mi (1,408.58 km) |
| La Crosse to Saratoga Springs (Utah) | 1,084.67 mi (1,745.61 km) |
| La Crosse to Sartell (Minnesota) | 192.27 mi (309.43 km) |
| La Crosse to Satellite Beach (Florida) | 1,230.97 mi (1,981.06 km) |
| La Crosse to Sauk Rapids (Minnesota) | 188.87 mi (303.95 km) |
| La Crosse to Sault Ste. Marie (Michigan) | 380.95 mi (613.07 km) |
| La Crosse to Savage (Minnesota) | 123.68 mi (199.04 km) |
