| La Crosse to Sanford (Maine) | 1,021.55 mi (1,644.02 km) |
| La Crosse to Sanford (North Carolina) | 860.11 mi (1,384.22 km) |
| La Crosse to Sanger (California) | 1,563.76 mi (2,516.63 km) |
| La Crosse to Santa Ana (California) | 1,586.37 mi (2,553.02 km) |
| La Crosse to Santa Barbara (California) | 1,648.90 mi (2,653.65 km) |
| La Crosse to Santa Clara (California) | 1,662.78 mi (2,675.99 km) |
| La Crosse to Santa Clara (Oregon) | 1,576.76 mi (2,537.56 km) |
| La Crosse to Santa Clarita (California) | 1,590.14 mi (2,559.09 km) |
| La Crosse to Santa Cruz (California) | 1,677.62 mi (2,699.87 km) |
| La Crosse to Santa Fe (New Mexico) | 963.30 mi (1,550.28 km) |
| La Crosse to Santa Fe (Texas) | 1,019.93 mi (1,641.42 km) |
| La Crosse to Santa Fe Springs (California) | 1,587.48 mi (2,554.80 km) |
| La Crosse to Santa Maria (California) | 1,666.07 mi (2,681.28 km) |
| La Crosse to Santa Monica (California) | 1,604.10 mi (2,581.54 km) |
| La Crosse to Santa Paula (California) | 1,619.92 mi (2,607.02 km) |
