| La Crosse to Oswego (Illinois) | 208.22 mi (335.10 km) |
| La Crosse to Oswego (New York) | 735.85 mi (1,184.24 km) |
| La Crosse to Otsego (Minnesota) | 154.31 mi (248.33 km) |
| La Crosse to Ottawa (Illinois) | 209.75 mi (337.56 km) |
| La Crosse to Ottawa (Kansas) | 417.40 mi (671.74 km) |
| La Crosse to Ottumwa (Iowa) | 203.08 mi (326.83 km) |
| La Crosse to Overland (Missouri) | 357.06 mi (574.63 km) |
| La Crosse to Overland Park (Kansas) | 385.35 mi (620.17 km) |
| La Crosse to Overlea (Maryland) | 818.70 mi (1,317.57 km) |
| La Crosse to Oviedo (Florida) | 1,185.74 mi (1,908.26 km) |
| La Crosse to Owasso (Oklahoma) | 574.59 mi (924.71 km) |
| La Crosse to Owatonna (Minnesota) | 101.38 mi (163.16 km) |
| La Crosse to Owensboro (Kentucky) | 470.92 mi (757.87 km) |
| La Crosse to Owings Mills (Maryland) | 804.18 mi (1,294.21 km) |
| La Crosse to Owosso (Michigan) | 358.39 mi (576.77 km) |
