| La Crosse to Orangevale (California) | 1,588.52 mi (2,556.48 km) |
| La Crosse to Orchards (Washington) | 1,531.44 mi (2,464.61 km) |
| La Crosse to Orcutt (California) | 1,667.30 mi (2,683.26 km) |
| La Crosse to Oregon (Ohio) | 422.85 mi (680.51 km) |
| La Crosse to Oregon (Wisconsin) | 111.23 mi (179.01 km) |
| La Crosse to Oregon City (Oregon) | 1,537.30 mi (2,474.05 km) |
| La Crosse to Orem (Utah) | 1,075.06 mi (1,730.14 km) |
| La Crosse to Orinda (California) | 1,658.36 mi (2,668.86 km) |
| La Crosse to Orland Park (Illinois) | 229.39 mi (369.16 km) |
| La Crosse to Orlando (Florida) | 1,193.22 mi (1,920.31 km) |
| La Crosse to Ormond Beach (Florida) | 1,148.14 mi (1,847.76 km) |
| La Crosse to Oro Valley (Arizona) | 1,325.88 mi (2,133.80 km) |
| La Crosse to Oroville (California) | 1,584.88 mi (2,550.61 km) |
| La Crosse to Oshkosh (Wisconsin) | 133.32 mi (214.56 km) |
| La Crosse to Oskaloosa (Iowa) | 189.14 mi (304.40 km) |
