| La Crosse to Olympia Heights (Florida) | 1,391.99 mi (2,240.20 km) |
| La Crosse to Omaha (Nebraska) | 302.70 mi (487.14 km) |
| La Crosse to On Top of the World Designated Place (Florida) | 1,130.12 mi (1,818.75 km) |
| La Crosse to Onalaska (Wisconsin) | 4.54 mi (7.30 km) |
| La Crosse to Oneida (New York) | 781.26 mi (1,257.32 km) |
| La Crosse to Oneonta (New York) | 818.89 mi (1,317.87 km) |
| La Crosse to Ontario (California) | 1,561.62 mi (2,513.19 km) |
| La Crosse to Ontario (Oregon) | 1,276.23 mi (2,053.89 km) |
| La Crosse to Opa-locka (Florida) | 1,382.93 mi (2,225.61 km) |
| La Crosse to Opelika (Alabama) | 833.49 mi (1,341.37 km) |
| La Crosse to Opelousas (Louisiana) | 920.05 mi (1,480.68 km) |
| La Crosse to Orange (California) | 1,580.92 mi (2,544.25 km) |
| La Crosse to Orange (Texas) | 956.83 mi (1,539.86 km) |
| La Crosse to Orange City (Florida) | 1,165.84 mi (1,876.23 km) |
| La Crosse to Orangeburg (South Carolina) | 905.07 mi (1,456.57 km) |
