| La Crosse to Enterprise (Nevada) | 1,375.38 mi (2,213.45 km) |
| La Crosse to Enumclaw (Washington) | 1,497.63 mi (2,410.21 km) |
| La Crosse to Ephrata (Pennsylvania) | 811.10 mi (1,305.35 km) |
| La Crosse to Erie (Colorado) | 755.47 mi (1,215.81 km) |
| La Crosse to Erie (Pennsylvania) | 575.61 mi (926.35 km) |
| La Crosse to Erlanger (Kentucky) | 478.21 mi (769.61 km) |
| La Crosse to Escanaba (Michigan) | 242.47 mi (390.22 km) |
| La Crosse to Escondido (California) | 1,571.72 mi (2,529.43 km) |
| La Crosse to Española (New Mexico) | 951.92 mi (1,531.97 km) |
| La Crosse to Essex (Maryland) | 824.11 mi (1,326.27 km) |
| La Crosse to Essex Junction (Vermont) | 897.18 mi (1,443.87 km) |
| La Crosse to Estelle (Louisiana) | 967.86 mi (1,557.61 km) |
| La Crosse to Estero (Florida) | 1,312.70 mi (2,112.58 km) |
| La Crosse to Euclid (Ohio) | 516.13 mi (830.63 km) |
| La Crosse to Eufaula (Alabama) | 886.74 mi (1,427.06 km) |
